Centellian24 Expert Madeca Cream Active Renew PDRN (50ml)
- Regular price £24.99
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- Centella and PDRN cream, no retinol
- For dry or tired-looking skin
- Last step, morning and night
- Contains essential oils
In stock. Order by 1pm Monday to Friday for same-day dispatch
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100% authentic K‑beauty- Hand-picked by our founder
Centellian24 Expert Madeca Cream Active Renew PDRN is a firming moisturiser for skin that has lost a bit of its bounce. Centellian24 pair their centella extract with PDRN from five sources (salmon, cica, rose, marine and heartleaf), then add ten types of hyaluronic acid, ceramides and caffeine. It's a smooth cream that feels comforting on dry, tired skin and, used morning and night, works on a firmer, plumper look over time. There's no retinol, so it fits into almost any routine.
What it does
PDRN is the ingredient behind Korea's salmon skincare trend. Here it sits in what Centellian24 call their TECA-5D PDRN complex: PDRN from five sources, which they say come in five molecular sizes, combined with the centella compounds the brand is built on (asiaticoside, madecassic acid and asiatic acid). Ten types of hyaluronic acid and glycerin keep skin moisturised, ceramide NP and panthenol help it feel comfortable, niacinamide helps even the look of skin tone, and caffeine gives tired-looking skin a fresher look. A blend of essential oils gives it a scent.
Why we chose it
We wanted a PDRN cream that works as an everyday moisturiser first. This one has no retinol, so you can use it morning and night next to the serum you already love. It comes from Centellian24, the skincare line of Dongkook Pharmaceutical, the Korean company behind Madecassol centella ointment. If you're curious about PDRN but don't want to rebuild your routine around it, this is the cream we'd pick.
Best for
- Dry or dehydrated skin that wants a comforting cream
- Skin that looks dull or tired
- The look of fine lines and loss of bounce
- A morning and evening moisturiser without a retinoid
Not ideal if
- You avoid fragrance or essential oils: it contains lavender, bergamot, orange, rosemary and chamomile oils. Purito Wonder Releaf Centella Cream (Unscented) is an unscented centella cream
- You avoid fish or animal-derived ingredients: Centellian24 say part of the PDRN comes from salmon, and the source of the collagen amino acids and hydrolysed elastin is not stated
Key ingredients
- Asiaticoside, madecassic acid and asiatic acid: centella compounds for comfort
- PDRN (sodium DNA): the centrepiece of the TECA-PDRN complex
- Niacinamide: helps even the look of skin tone
- Ceramide NP, phytosterols and ten forms of hyaluronic acid: moisture and barrier support
- Adenosine: the look of fine lines
Texture and finish
A smooth, soft cream that gently hugs the skin for a comfortable finish. It comes in a 50 ml tube.
Where it goes in your routine
The last step after serum, morning and evening. In the morning, follow with sunscreen.
What to expect
Skin feels more moisturised and comfortable straight after applying. In Centellian24's own test on 22 people (Korea Dermatology Research Institute, June to July 2025), skin elasticity measured 25.56% better after one use. Results vary from person to person, and the look of firmness builds with steady use.
Good to know
It contains essential oils. Centellian24 say part of the PDRN is salmon-derived; the collagen amino acids and hydrolysed elastin may also be animal-derived. Do not use it on broken skin or wounds. We checked the ingredient list against the carton of our current stock.
Quick facts: 50 ml tube · Centella, PDRN, niacinamide · No retinol · Contains essential oils · Morning and night · Centellian24, made in Korea
What is PDRN in Centellian24 Expert Madeca Cream?
PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient, often sourced from salmon, that Korean brands use in creams and serums for the look of bouncier, more resilient skin. In this cream it's listed as sodium DNA, and Centellian24 say it comes from five sources: salmon, cica, rose, marine and heartleaf.
What does Centellian24 Expert Madeca Cream Active Renew PDRN do?
It is a moisturiser for dry or tired-looking skin. Centella compounds and panthenol help skin feel calm, ceramide NP and ten forms of hyaluronic acid help keep it moisturised, niacinamide helps even the look of tone, and Centellian24 add PDRN (sodium DNA) and adenosine for the look of smoother, bouncier skin over time.
What is the difference between Centellian24 Madeca Cream Time Reverse and Expert Madeca Cream Active Renew PDRN?
Both are centella creams from Centellian24. Time Reverse contains retinol, so it is best introduced slowly in the evening. Expert Madeca Cream Active Renew PDRN has no retinol and is built around PDRN, ceramide NP and ten forms of hyaluronic acid, so it can be used morning and night from the start.
Is the PDRN in Centellian24 Expert Madeca Cream from salmon?
Partly. Centellian24 say their PDRN comes from five sources: salmon, cica, rose, marine and heartleaf. If you avoid fish-derived ingredients, this cream is not for you.
Can I use Centellian24 Expert Madeca Cream Active Renew PDRN morning and night?
Yes. Centellian24 recommend it as the last step morning and evening. In the morning, follow with sunscreen.
Does Centellian24 Expert Madeca Cream Active Renew PDRN have a scent?
Yes. It contains essential oils, including lavender, bergamot, orange, rosemary and chamomile. If you avoid fragrance, Purito Wonder Releaf Centella Cream (Unscented) is the unscented option.
Can sensitive skin use Centellian24 Expert Madeca Cream Active Renew PDRN?
Centellian24 say it helps comfort sensitive skin, and the centella compounds, panthenol and ceramides are there for that. It also contains essential oils, which can bother reactive skin. If your skin reacts to fragrance, an unscented centella cream is the safer place to start.
- Use as the last step of your skincare, morning and evening.
- Smooth a small amount over face and neck.
- In the morning, follow with sunscreen.
Water, Glycerin, Dipropylene Glycol, Caprylic/Capric Triglyceride, Hydrogenated Poly(C6-14 Olefin), Glyceryl Stearate, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Methyl Trimethicone, Vinyldimethicone, Cetearyl Alcohol, Rosa Damascena Flower Water, Polyglyceryl-10 Laurate, 1,2-Hexanediol, C10-18 Triglycerides, Panthenol, Sodium Stearoyl Glutamate, Sodium Polyacryloyldimethyl Taurate, Butylene Glycol, Jojoba Esters, Glyceryl Stearates, Hydroxyacetophenone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Stearyl Alcohol, Sodium DNA, Behenyl Alcohol, Asiaticoside, Madecassic Acid, Helianthus Annuus Seed Wax, Coptis Japonica Root Extract, Ethylhexylglycerin, Lavandula Angustifolia Oil, Citrus Aurantium Bergamia Fruit Oil, Asiatic Acid, Olea Europaea Fruit Oil, Citrus Aurantium Dulcis Peel Oil, Xanthan Gum, Rosmarinus Officinalis Leaf Oil, Disodium EDTA, Adenosine, Centella Asiatica Extract, Sorbitan Isostearate, Polyglycerin-3, Anthemis Nobilis Flower Oil, Cyanocobalamin, Ascorbic Acid, Tocopherol, Caffeine, Glutathione, Beta-Sitosterol, Ceramide NP, Phytosterols, Glycoproteins, Phytosphingosine, Hydrogenated Lecithin, Ulmus Davidiana Root Extract, Viola Mandshurica Flower Extract, Aloe Barbadensis Leaf Extract, Dioscorea Japonica Root Extract, Laminaria Japonica Extract, Collagen Amino Acids, Hydrolyzed Elastin, Sodium Hyaluronate, Dimethylsilanol Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Aspartic Acid, Potassium Hyaluronate, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Glycine, Arginine, Glutamic Acid, Limonene, Linalool, Citrus Aurantium Peel Oil
Good to know
- Contains essential oils, including lavender, bergamot, orange, rosemary and chamomile
- PDRN partly salmon-derived (per Centellian24); collagen amino acids and hydrolysed elastin: source not stated
- No retinoid listed
- Checked against the carton of our current stock (October 2026)
UK Delivery
Orders under £25
Shipping: £2.99
Service: Royal Mail Tracked 48
Orders £25 and over
Shipping: FREE
Service: Royal Mail Tracked 24
Dispatch & Delivery Times
- Orders placed before 1pm Monday to Friday are dispatched the same working day.
- Orders placed after 1:00 PM are dispatched the next working day.
- Royal Mail Tracked 48 typically delivers within 2 working days.
- Royal Mail Tracked 24 aims for next working day delivery.
So for orders £25 and over placed before 1pm on a working day:
Order before 1pm → dispatched same day → Royal Mail Tracked 24 aims to deliver the next working day.
Please note that delivery times are estimates and may occasionally vary during busy periods, bank holidays or due to Royal Mail delays.